6th Edition of Neurology World Conference 2026

Abstract

Introduction: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by autoimmune demyelination, leading to synaptic conduction defects. This condition affects approximately 2.5 million individuals globally, primarily women aged 20 to 45, with a higher prevalence in temperate regions. Due to the lack of scientific data on the effectiveness of concurrent training combined with therapeutic approaches for MS patients, this study aimed to investigate the impact of an eight-week concurrent (aerobic-resistance) training program on aerobic power and functional capacity in young female MS patients.

Methods: The study was conducted in accordance with the Declaration of Helsinki Principles and Patient Rights using a pre- and posttest design. Forty-seven female MS patients were randomly assigned to either an experimental group (27 subjects; average age 28.74 ± 3.07 years; BMI 31.9 ± 4.32 kg/m2; disability range 1-4) or a control group (20 subjects; average age 28.20 ± 4.11 years; BMI 30.43 ± 4.57 kg/m2; disability range 1-4). Participants underwent assessments before and after the intervention, including tests for 10- and 500-meter walking speed, balance, fatigue, and aerobic power. The experimental group followed an eight-week concurrent training program (3 sessions per week consisting of a 10-minute warm-up, 15 minutes of aerobic exercise at 60-75% maximum heart rate, 25 minutes of weight training at 10-repetition maximum (10RM), and a 5-minute cool-down), while the control group only received prescribed medications. Data analysis involved the use of T-tests for dependent and independent samples.

Results: The findings revealed significant improvements in fatigue, balance, and walking speed in the experimental group (P<0.05); however, no significant changes were observed in the patients' aerobic power.

Conclusion: The study suggests that concurrent training, such as an aerobic-resistance program, can enhance walking speed, balance, and reduce fatigue in women with multiple sclerosis. Therefore, incorporating such exercises is recommended to improve the movement and functional status of these patients.