Abstract

Chronic relapsing inflammatory optic neuropathy (CRION) is distinct from both Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO). CRION is primarily linked to the presence of Myelin oligodendrocyte glycoprotein (MOG) antibodies, although there are cases where it may also be negative. CRION is a medical condition characterized by recurring episodes of optic neuritis that improve with the use of steroids but return once the steroids are stopped. To conduct this study, the authors meticulously conducted a thorough literature search that specifically examined CRION and its correlation with MOG. We identified 9 papers for our research study by utilizing keywords such as CRION, MOG antibodies, and optic neuritis. Our study revealed that the majority of CRION patients were females, accounting for 58% of the cases. Additionally, 90% of those with the disease tested positive for MOG antibodies. The clinical characteristics of the patients included a varying number of optic neuritis episodes, ranging from 3 to 30 episodes. Out of the patients, 4 experienced optic disc edema, and some patients experienced vision loss because of optic neuritis. The MOG titers varied between 1:100 to 1:640. This article will explore several studies that examine the diverse clinical manifestations in MOG-positive CRION patients, as well as the MRI brain findings, optical coherence tomography test, and therapeutic options for these individuals.