Abstract

The aim of this meta-analysis was to comprehensively evaluate the existing evidence regarding the effectiveness of rehabilitation interventions in patients with myasthenia gravis (MG), focusing specifically on outcomes related to functional mobility and respiratory capacity, as measured by the six-minute walk test (6MWT) and pulmonary function parameters. This study seeks to bridge a crucial gap in the understanding of non-pharmacologic interventions in MG, a domain often underrepresented in clinical guidelines.
Materials and Methods
We searched PubMed and the Cochrane Database for any study conducted on MG patients receiving a rehabilitation program, including physical therapy, respiratory training, or combined approaches. There were no restrictions on the type, frequency, or duration of rehabilitation, allowing for a broad synthesis of clinical practices. The primary endpoints were 6MWT and FEV1 at the longest available follow-up. 
Results
Over 150 patients with myasthenia gravis were included in this analysis. MG patients demonstrated both statistically and clinically meaningful improvements following rehabilitation compared to their pre-rehabilitation status. Functional exercise capacity, as measured by the six-minute walk test (6MWT), showed a clear upward trend. Pulmonary function improvement was also observed, with forced expiratory volume in one second (FEV1) demonstrating consistent positive changes. Analysis indicated that rehabilitation programs incorporating physical therapy may be more effective in enhancing respiratory outcomes than respiratory-specific interventions alone. These findings suggest the potential benefit of integrative rehabilitation strategies that combine motor and respiratory components.
Conclusions
Rehabilitation appears to significantly enhance both functional exercise capacity and pulmonary function in MG patients, as seen by improved 6MWT performance and FEV1. These findings emphasize the therapeutic value of structured rehabilitation programs as an adjunct to conventional MG management.