6th Edition of Neurology World Conference 2026

Abstract

There are currently no approved pharmacological therapies for the core symptoms of autism spectrum disorder (ASD), prompting nearly half of patients or their caregivers to seek complementary and alternative medicine approaches. There is now compelling clinical and basic scientific evidence that megavitamin therapy can relieve core symptoms of ASD, possibly by modulating cellular energy metabolism and oxidative stress.
Based on these data and the underlying rationale, a new integrative medicine approach was designed for ASD patients that combined B- and C-vitamin megavitamin therapy with a complex isopathic preparation designed to target the core features of ASD pathobiology. This approach was tested in a 7-year-old child with ASD after written consent was obtained from his parents, who were seeking a radical change in therapy due to very little or no progress after years of specialized rehabilitation.
Promoting brain plasticity in the developing brain involves stimulating the growth of neural structures, including intense neurogenesis, synaptogenesis, and myelination. In addition to food, introducing essential nutrients such as vitamins to the brain is therefore a rational approach.
We decided to supplement parenteral vitamin C and vitamins B1, B6, and B12 in megadoses, along with folinic acid at a regular dose, combined with an isopathic mixture of Krebs cycle elements in a product called Coenzyme Compositum from a German manufacturer. The rationale for parenteral supplementation was to avoid possible gastrointestinal dysfunctions affecting absorption. The rationale for megadosing was to avoid relative vitamin deficiencies, considering principles of biochemical individuality.
The patient was a 7-year-old child with grade 2 ASD, presenting with typical symptoms including limited speech, social withdrawal, and cognitive delay, with a CARS-2   ST score of 31.
After 25 sessions of the protocol, the patient showed significant improvement in cognition, speech, social interaction, and behavior, (CARS.-2  ST   , score  of 24)suggesting that this treatment concept for children with ASD is worthy of further evaluation.-