Miami, Florida, USA
6th Edition of Neurology World Conference 2026
Speakers - NWC 2025
Henry Taylor
- Designation: The University of Oxford
- Country: UK
Biography
Abstract: Alzheimer’s Disease is characterised by accumulation of plaques of aggregated amyloid and intracellular hyperphosphorylated tau. The mechanistic links between these two histopathological phenomena are as yet unknown. Soluble oligomeric assemblies of amyloid (Ao) drive disease pathology and have immediate effects at the synapse. Specifically, they attenuate long-term potentiation (LTP), and facilitate long-term depression (LTD), accompanied by postsynaptic weakening. We show that this is achieved by enhancement of presynaptic neurotransmitter release. Evidence suggests that tau plays a physiological role in LTD induction, requiring its phosphorylation at several sites. We probed the synaptic effects of Ao, specifically focussing on its presynaptic actions and its links to LTD. We demonstrate that Ao increase tau phosphorylation at disease-associated sites, and furthermore, that chronic, repetitive induction of NMDAR-dependent LTD via optogenetic stimulation can mimic this effect. This suggests a possible mechanistic link between aberrant Ao aggregation and pathological tau phosphorylation that could have an important implications on AD therapy
Neurology World Conference (NWC 2026): Promotes the talks in Advancing the Brain He ...
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